Invention Grant
- Patent Title: Stabilized liquid anti-RSV antibody formulations
-
Application No.: US15852023Application Date: 2017-12-22
-
Publication No.: US10604560B2Publication Date: 2020-03-31
- Inventor: Cynthia N. Oliver , Erica Shane , Benjamin S. Isaacs , Christian B. Allan , Stephen T. Chang
- Applicant: Arexis AB
- Applicant Address: SE Stockholm
- Assignee: Arexis AB
- Current Assignee: Arexis AB
- Current Assignee Address: SE Stockholm
- Agency: Mueting, Raasch & Gebhardt, P.A.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/10 ; A61K9/00 ; A61K47/18 ; A61K47/26 ; C07K16/00 ; A61K39/42 ; A61K47/22 ; A61K39/00

Abstract:
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
Public/Granted literature
- US20180230202A1 STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS Public/Granted day:2018-08-16
Information query