Exemplary systems, methods and computer accessible mediums which can determine quantitative information of a tissue(s) can be provided, which can include receiving optical information regarding the tissue(s), and determining the quantitative information of the tissue(s), in real time and during the receipt of the optical information, using an atlas. The tissue(s) can be part of a mouse, and the quantitative information can be an in-vivo count of cells or bacteria in the tissue(s). The quantitative information can be determined by co-registering the in-vivo count to the atlas. The optical information can be generated using a mirror gantry(s) so as to simultaneously image at least two opposing views of the tissue(s).