A portable information handling system processes information with processing components disposed in a main housing portion and presents the information at a display disposed in a lid housing portion. A keyboard and touchpad disposed at the upper surface of the main housing portion accept end user inputs. The touchpad translates touch inputs at a touch detection surface into cursor movement at the display and accepts presses at a touch button as input clicks. One or more antenna integrated in the touchpad to support communication of wireless signals by a transceiver disposed in the main housing, such as to support wireless local area network communications. A ground plane of the touchpad forms openings under the one or more antenna to provide a pathway for the wireless signals.