Technical solutions are described for issuing, by a load-store unit (LSU), a plurality of instructions from an out-of-order (OoO) window. The issuing includes, in response to determining a first effective address being used by a first instruction, the first effective address corresponding to a first real address, creating an effective real table (ERT) entry in an ERT, the ERT entry mapping the first effective address to the first real address. Further, the execution includes in response to determining an effective address synonym used by a second instruction, the effective address synonym being a second effective address that is also corresponding to said first real address: creating a synonym detection table (SDT) entry in an SDT, wherein the SDT entry maps the second effective address to the ERT entry, and relaunching the second instruction by replacing the second effective address in the second instruction with the first effective address.