A computer-implemented method for prognostic network management may include (1) monitoring a health indicator of a physical component of a device in a network, (2) using the health indicator to estimate a remaining useful life of the physical component, (3) detecting that the remaining useful life of the physical component has reached a predetermined threshold, and (4) reconfiguring the network in response to detecting that the remaining useful life of the physical component has reached the predetermined threshold so that failure of the physical component does not cause the network to become unavailable to any user of the network. Various other methods, systems, and computer-readable media are also disclosed.