A method and system for non-disruptive host repurposing. Specifically, the method and system disclosed herein entail the re-optimization of datacenter hosts (e.g., servers) for any infrastructure and/or workload deployment. Different infrastructure and/or workload deployments may require the tuning of various memory parameters (or attributes) in the basic input-output system (BIOS) configuration. Presently, the repurposing of any given host demands the full reset of the system configuration—i.e., a disruptive process—prior to implementing the necessary BIOS configuration changes. In contrast, the method and system disclosed herein facilitate the repurposing of a host through the installation and/or uninstallation of configuration overlays—a modular approach to interchanging infrastructure and/or workload deployments—without the disruption of full system resets.