The present disclosure describes systems and methods for pressure-driven micro-surgical tool actuation. The systems and methods may encompass the use of a remote handle held by a first hand of a user as well as a surgical tool located in the eye of a patient. A primary actuator may be included in remote handle and operable to be actuated by a mechanical force exerted on the handle. Actuating the primary actuator pressurizes a fluid within a length of tubing. The pressurized fluid may be transmitted to a dynamic tool held by a second hand of the user, where the pressurized fluid may be used to actuate a subordinate actuator. Actuation of the subordinate actuator may actuate a dynamic component of the dynamic tool.