Invention Grant
- Patent Title: Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
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Application No.: US15649568Application Date: 2017-07-13
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Publication No.: US10646488B2Publication Date: 2020-05-12
- Inventor: Yi Liu , Liansheng Li , Pingda Ren
- Applicant: Araxes Pharma LLC
- Applicant Address: US CA San Diego
- Assignee: ARAXES PHARMA LLC
- Current Assignee: ARAXES PHARMA LLC
- Current Assignee Address: US CA San Diego
- Agency: Seed Intellectual Property Law Group LLP
- Main IPC: A61K31/517
- IPC: A61K31/517 ; A61K47/54
Abstract:
Conjugates of a cereblon-binding compound and compounds having modulatory activity against G12C mutant KRAS, HRAS or NRAS G12C proteins are provided. Methods associated with preparation and use of such conjugates, pharmaceutical compositions comprising such conjugates and methods to modulate the activity of G12C mutant KRAS, HRAS or NRAS G12C proteins for treatment of disorders, such as cancer, are also provided.
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