Invention Grant
- Patent Title: Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
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Application No.: US16425778Application Date: 2019-05-29
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Publication No.: US10646517B2Publication Date: 2020-05-12
- Inventor: Seth Wardell , James Bender , Michael T. Lotze
- Applicant: Iovance Biotherapeutics, Inc.
- Applicant Address: US CA San Carlos
- Assignee: Iovance Biotherapeutics, Inc.
- Current Assignee: Iovance Biotherapeutics, Inc.
- Current Assignee Address: US CA San Carlos
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K35/26
- IPC: A61K35/26 ; C12N5/078 ; A61K35/17 ; A61K38/20 ; A61K31/675 ; A61K31/7076 ; A61P35/00 ; A61K9/00 ; A01N1/02 ; C12N5/0783
Abstract:
The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
Information query
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