Invention Grant
- Patent Title: Methods and compositions for CNS delivery of arylsulfatase A
-
Application No.: US15684568Application Date: 2017-08-23
-
Publication No.: US10646554B2Publication Date: 2020-05-12
- Inventor: Nazila Salamat-Miller , Katherine Taylor , Paul Campolieto , Zahra Shahrokh , Jing Pan , Lawrence Charnas , Teresa Leah Wright , Pericles Calias
- Applicant: Shire Human Genetic Therapies, Inc.
- Applicant Address: US MA Lexington
- Assignee: Shire Human Genetic Therapies, Inc.
- Current Assignee: Shire Human Genetic Therapies, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Proskauer Rose LLP
- Agent Fangli Chen
- Main IPC: A61K38/47
- IPC: A61K38/47 ; A61K35/76 ; A61K35/761 ; A61K9/19 ; C12N9/24 ; A61K9/00 ; A61K38/46 ; C07K14/65 ; C12N9/42 ; A61K9/08 ; A61K47/02 ; A61K47/26
Abstract:
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.
Public/Granted literature
- US20180071212A1 METHODS AND COMPOSITIONS FOR CNS DELIVERY OF ARYLSULFATASE A Public/Granted day:2018-03-15
Information query
IPC分类:
