Invention Grant
- Patent Title: HER2 polypeptides useful for imaging and monitoring tumors and cancers
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Application No.: US14900841Application Date: 2014-06-24
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Publication No.: US10646600B2Publication Date: 2020-05-12
- Inventor: Duncan Robert R. Hiscock , Eric Aboagye , Peter Iveson , Quang-De Nguyen , Susan Hoppmann , Sebastian Trousil , Maciej Kaliszczak , Giampaolo Tomasi
- Applicant: GE HEALTHCARE LIMITED , IMPERIAL INNOVATIONS LIMITED
- Applicant Address: GB London GB Buckinghamshire
- Assignee: IMPERIAL INNOVATIONS LIMITED,GE HEALTHCARE LIMITED
- Current Assignee: IMPERIAL INNOVATIONS LIMITED,GE HEALTHCARE LIMITED
- Current Assignee Address: GB London GB Buckinghamshire
- Agency: Arent Fox, LLP
- International Application: PCT/SE2014/050774 WO 20140624
- International Announcement: WO2014/209205 WO 20141231
- Main IPC: A61K51/04
- IPC: A61K51/04 ; A61K51/10 ; G01N33/60
Abstract:
A method of use of an isolated polypeptide conjugated with a radionuclide, wherein the isolated polypeptide binds specifically to HER2, or a variant thereof is described. The method is for monitoring the response to HSP90 inhibition and comprises the use of the isolated polypeptide conjugated with 18F. The application also describes the use of an isolated polypeptide conjugated with 18F, wherein the isolated polypeptide binds specifically to HER2 or variants thereof, as an imaging agent to monitor uptake thereof to measure HSP90 inhibition.
Public/Granted literature
- US20160144062A1 USE OF HER2 BINDERS Public/Granted day:2016-05-26
Information query
