Invention Grant
- Patent Title: Method for manufacturing bone-regeneration material comprising biodegradable fibers by using electrospinning method
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Application No.: US15773554Application Date: 2017-04-28
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Publication No.: US10646616B2Publication Date: 2020-05-12
- Inventor: Toshihiro Kasuga , Yasutoshi Nishikawa
- Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY , ORTHOREBIRTH CO.LTD.
- Applicant Address: JP Nagoya JP Yokohama
- Assignee: National University Corporation Nagoya Institute of Technology,Orthorebirth Co., Ltd.
- Current Assignee: National University Corporation Nagoya Institute of Technology,Orthorebirth Co., Ltd.
- Current Assignee Address: JP Nagoya JP Yokohama
- Agency: Liang Legal Group, PLLC
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4cfe1f53
- International Application: PCT/JP2017/016931 WO 20170428
- International Announcement: WO2017/188435 WO 20171102
- Main IPC: B29B7/10
- IPC: B29B7/10 ; B29B7/12 ; B29B7/14 ; B29B7/38 ; B29B7/40 ; B29B7/42 ; B29B7/84 ; C08G63/08 ; C08J3/20 ; A61L27/18 ; A61L27/58 ; D01F6/62 ; D01D5/08 ; A61L27/46 ; D01F1/02 ; A61L27/56 ; D01D5/00 ; A61L27/12 ; A61L27/54 ; D01D1/02 ; D01F1/10 ; B29B13/00 ; C08K3/32

Abstract:
A bone-regeneration material that contains calcium phosphate particles in biodegradable fibers of PLGA manufactured by electrospinning. A PLGA resin is heated in a kneader until the resin viscosity becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is added while the blade is rotated. The mixture is kneaded by continuous rotation of the blade in the heated state to disperse the calcium phosphate fine particles to obtain a composite having calcium phosphate fine particles dispersed in the PLGA resin. The composite is dissolved by a solvent, and the PLGA resin is completely dissolved by agitation for a prescribed duration to prepare a spinning solution in which the calcium phosphate fine particles are dispersed. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
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