A method and a device for specifying an operating strategy profile for the operation of a motor vehicle, and a method and a central database device for specifying a global geo-referenced operating strategy profile with regard to a driving route are provided. The following steps are executed: transmitting driving route data that characterize a scheduled driving route for an upcoming journey of the vehicle to a central database device; receiving operating strategy data from the central database device, which data characterize a proposed geo-referenced global operating strategy profile defined with respect to the driving route for the operation of the vehicle during its journey on the driving route; sensor-based acquisition of operating data that characterize an operating status and/or a driving situation of the vehicle during its journey on the driving route, and determining a local operating strategy profile for the operation of the vehicle during its continued journey on the driving route on the basis of the acquired operating data; specification of an operating strategy profile to be applied for the operation of the vehicle on the basis of the global operating strategy profile and the local operating strategy profile; and application of the specified operating strategy profile for the operation of the vehicle on the driving route.