Invention Grant
- Patent Title: Biaryl derivative and medicine containing same
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Application No.: US15759125Application Date: 2016-09-14
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Publication No.: US10647675B2Publication Date: 2020-05-12
- Inventor: Atsushi Watanabe , Yuuki Sato , Keiji Ogura , Yoshiyuki Tatsumi
- Applicant: KAKEN PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: KAKEN PHARMACEUTICAL CO., LTD.
- Current Assignee: KAKEN PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@41446178
- International Application: PCT/JP2016/077029 WO 20160914
- International Announcement: WO2017/047602 WO 20170323
- Main IPC: C07D213/643
- IPC: C07D213/643 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D401/12 ; C07D239/34 ; C07D417/14 ; C07D471/04 ; C07D498/04 ; C07D213/65 ; A61K31/535 ; A61K31/444 ; A61K31/5355 ; A61K31/4709 ; C07D241/18 ; C07D213/64 ; A61K31/4425 ; A61K31/4725 ; A61K31/4985 ; A61K31/506 ; A61K31/498 ; A61P31/10 ; C07D213/68 ; C07D213/76 ; C07D401/04 ; C07D487/04 ; C07F7/08

Abstract:
Provided is a compound showing excellent Antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C═O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.
Public/Granted literature
- US20190055199A1 BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME Public/Granted day:2019-02-21
Information query
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