Invention Grant
- Patent Title: Tetrahydroisoquinoline derived PRMT5-inhibitors
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Application No.: US15508063Application Date: 2015-09-03
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Publication No.: US10647708B2Publication Date: 2020-05-12
- Inventor: Richard Charles Foitzik , Michelle Ang Camerino , Scott Raymond Walker , H. Rachel Lagiakos
- Applicant: CTXT PTY LTD
- Applicant Address: AU Victoria
- Assignee: CTXT PTY. LTD
- Current Assignee: CTXT PTY. LTD
- Current Assignee Address: AU Victoria
- Agency: Stites & Harbison PLLC
- Agent Richard S. Myers, Jr.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5ff0f69b
- International Application: PCT/EP2015/070155 WO 20150903
- International Announcement: WO2016/034675 WO 20160310
- Main IPC: C07D217/04
- IPC: C07D217/04 ; C07D413/14 ; C07D401/14 ; C07D231/12 ; C07D295/192 ; C07D239/42 ; C07D271/10 ; C07D401/12 ; C07D405/12 ; C07D413/12

Abstract:
A compound of formula (I) wherein: R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.
Public/Granted literature
- US20170283407A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS Public/Granted day:2017-10-05
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