Invention Grant
- Patent Title: Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
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Application No.: US15305409Application Date: 2015-04-21
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Publication No.: US10647718B2Publication Date: 2020-05-12
- Inventor: Guy Sauvageau , Yves Gareau , Stéphane Gingras
- Applicant: UNIVERSITÉ DE MONTRÉAL
- Applicant Address: CA Montréal
- Assignee: UNIVERSITÉDE MONTRÉAL
- Current Assignee: UNIVERSITÉDE MONTRÉAL
- Current Assignee Address: CA Montréal
- Agency: Norton Rose Fulbright Canada LLP
- International Application: PCT/CA2015/050330 WO 20150421
- International Announcement: WO2015/161373 WO 20151029
- Main IPC: C07D471/14
- IPC: C07D471/14 ; A61K35/28 ; C07D471/04 ; A61K31/5377 ; A61K31/519 ; A61K31/4545 ; A61K45/06 ; A61K31/444 ; A61P43/00 ; A61P35/00

Abstract:
Compounds of general formula or salts or prodrugs thereof, are provided and described herein. The compounds are useful to expand hematopoietic stem cell and/or hematopoietic progenitor cell populations. Particularly, the hematopoietic cells are human cells. The compounds are also useful in the medical treatment of hematopoietic disorder/malignancy, an autoimmune disease and/or an inherited immune-deficient disease in a subject.
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