Invention Grant
- Patent Title: Antibodies specific for hyperphosphorylated tau and methods of use thereof
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Application No.: US16371902Application Date: 2019-04-01
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Publication No.: US10647762B2Publication Date: 2020-05-12
- Inventor: Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@39226eeb com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@61be037a com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@30fc4462 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4cfbc252
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K49/00 ; A61K39/395 ; A61K39/00 ; G01N33/68
Abstract:
The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
Public/Granted literature
- US20190284266A1 ANTIBODIES SPECIFIC FOR HYPERPHOSPHORYLATED TAU AND METHODS OF USE THEREOF Public/Granted day:2019-09-19
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