Invention Grant
- Patent Title: Methods and materials for expanding antigen-specific T cells in culture
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Application No.: US15754216Application Date: 2016-08-12
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Publication No.: US10647961B2Publication Date: 2020-05-12
- Inventor: Peter A. Cohen , Sandra J. Gendler , Latha B. Pathangey , Dustin B. McCurry , Jessica E. Gorman , Mary L. Disis
- Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , UNIVERSITY OF WASHINGTON
- Applicant Address: US MN Rochester US WA Seattle
- Assignee: Mayo Foundation for Medical Education and Research,University of Washington
- Current Assignee: Mayo Foundation for Medical Education and Research,University of Washington
- Current Assignee Address: US MN Rochester US WA Seattle
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2016/046816 WO 20160812
- International Announcement: WO2017/034833 WO 20170302
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; A61K39/00
Abstract:
This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
Public/Granted literature
- US20180245042A1 METHODS AND MATERIALS FOR EXPANDING ANTIGEN-SPECIFIC T CELLS IN CULTURE Public/Granted day:2018-08-30
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