Invention Grant
- Patent Title: Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products
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Application No.: US15120037Application Date: 2015-02-20
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Publication No.: US10648004B2Publication Date: 2020-05-12
- Inventor: Marguerite A. Cervin , Michael C. Miller , Derek H. Wells , Alan J. Wolfe , Madhukar S. Dasika
- Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
- Applicant Address: US CA Palo Alto US OH Akron
- Assignee: Danisco US Inc.,The Goodyear Tire & Rubber Company
- Current Assignee: Danisco US Inc.,The Goodyear Tire & Rubber Company
- Current Assignee Address: US CA Palo Alto US OH Akron
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo PC
- International Application: PCT/US2015/016954 WO 20150220
- International Announcement: WO2015/127305 WO 20150827
- Main IPC: C12P5/00
- IPC: C12P5/00 ; C12N9/10 ; C12N9/88 ; C12N15/52 ; C12P7/42
Abstract:
The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, isoprenoids, and/or acetyl-CoA-derived products in recombinant microorganisms by engineering the microorganisms to comprise one or more acetylating proteins such that the expression and/or activity of the one or more acetylating proteins is modulated.
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