Invention Grant
- Patent Title: Methods and systems for nucleic acid sequencing by tunneling recognition
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Application No.: US16218938Application Date: 2018-12-13
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Publication No.: US10648029B2Publication Date: 2020-05-12
- Inventor: Yann Astier
- Applicant: Roche Sequencing Solutions, Inc.
- Applicant Address: US CA Pleasanton
- Assignee: Roche Sequencing Solutions, Inc.
- Current Assignee: Roche Sequencing Solutions, Inc.
- Current Assignee Address: US CA Pleasanton
- Agency: Kilpatrick Townsend and Stockton LLP
- Main IPC: C12Q1/6869
- IPC: C12Q1/6869 ; G01N27/327 ; G01N33/487

Abstract:
Embodiments may include a method of analyzing a nucleic acid molecule. The method may include attaching the nucleic acid molecule to a protein. The protein may be attached to a particle with a first diameter. The method may also include applying an electric field to move a first portion of the nucleic acid molecule into an aperture. The aperture may be defined by a first electrode, an insulator, and a second electrode. The aperture may have a second diameter less than the first diameter. The method may further include contacting the first portion of the nucleic acid molecule to both the first electrode and the second electrode. The method may include applying a voltage across the first electrode and the second electrode. The current through the electrodes and the portion of the nucleic acid molecule may be measured, and a nucleotide of the nucleic acid molecule may be identified.
Public/Granted literature
- US20190112652A1 METHODS AND SYSTEMS FOR NUCLEIC ACID SEQUENCING BY TUNNELING RECOGNITION Public/Granted day:2019-04-18
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