A release cable assembly having a release cable and an inertial locking device is provided. The release cable includes a cable wire configured to operably interconnect a release handle to a moveable latch release component of a latch assembly. The inertial locking device is configured to normally permit translational movement of the cable wire, via actuation of the release handle, to move the latch release component from a latched position to an unlatched position when the inertial locking device is exposed to an acceleration that is less than a predetermined acceleration threshold. When the inertial locking device is exposed to an acceleration exceeding the predetermined acceleration threshold, the inertial locking device prevents translational movement of the release cable, thereby preventing unintentional movement of the latch release component from the latched position to the unlatched position.