Invention Grant
- Patent Title: In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
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Application No.: US15983385Application Date: 2018-05-18
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Publication No.: US10648968B2Publication Date: 2020-05-12
- Inventor: Maciej Czerwinski , David Benjamin Buckley , Faraz Kazmi
- Applicant: XenoTech, LLC
- Applicant Address: US KS Kansas City
- Assignee: XenoTech, L.L.C.
- Current Assignee: XenoTech, L.L.C.
- Current Assignee Address: US KS Kansas City
- Agency: Hovey Williams LLP
- Main IPC: G01N33/50
- IPC: G01N33/50
Abstract:
A method for evaluating in vitro the effect of a xenobiotic (e.g., a drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in vitro xenobiotic-stimulated biological sample, and instructions for incubating the first culture of hepatocytes with the portion of in vitro xenobiotic-stimulated biological sample, and analyzing the activity, expression, or a combination thereof of a biomarker in the hepatocytes to evaluate the effect of the xenobiotic on drug metabolism in the hepatocytes.
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