The present disclosure relates to a disaggregated computing architecture comprising: a first compute node (302) comprising an interconnect interface (310); an accelerator node (304) comprising a physical device (402); and an interconnection network (308) linking the first compute node (302) and the accelerator node (304), wherein: the first compute node (302) executes a host operating system (410) and instantiates a first virtual machine (VM) executing a guest device driver (406) for driving the physical device; one or more input registers of the physical device are accessible via a first uniform physical address range (upa_a_devctl) of the interconnection network (308); and the interconnect interface (310) of the first compute node (302) is configured to map a host physical address range (hpa_c_devctl) of the host operating system (410) to the first uniform physical address range (upa_a_devctl).