Systems and methods for establishing connections and routing data via high-density cabling are described herein. In one or more embodiments, a network switch or other device maps different respective subsets of differential pairs in a cable to different respective network nodes of a plurality of network nodes that are connected to the network device via the cable. The network device then receives a data packet for a particular network node of the plurality of network nodes that are connected to the network device via the cable. Responsive to receiving the data packet, the network device identifies a particular subset of differential pairs in the cable that are mapped to the particular network node. The network device then sends the data packet of the particular subset of differential pairs to the particular network node.