Disclosed herein are systems and techniques for digital interfaces over a two-wire communication bus. For example, an electronic device to interface between a two-wire communication bus and a non-native digital interface may include: a digital interface to support a first digital interface protocol; and a transceiver, coupled to the digital interface, to couple to a link of the two-wire communication bus and to receive data via the link, wherein the data includes commands in accordance with a second digital interface protocol different from the first digital interface protocol; wherein the digital interface is to transmit the commands to a peripheral device in accordance with the second digital interface protocol.