A self-propelled agricultural sprayer can be configured with a spray boom, adjustable width wheels and rear wheel spray nozzles arranged over rear wheels of the adjustable width wheels, so that the rear wheel nozzles ensure proper coverage of an agricultural field behind the rear wheels according to location. A control system can determine front wheel nozzles disposed on the spray boom that are counterpart spray nozzles to the rear wheel nozzles based on a width of the wheels, and implement activation/deactivation states of the rear wheel nozzles based on the counterpart front spray nozzles. The activation/deactivation states of the spray nozzles can be determined by geographic location of the machine using a UPS location. The rear wheel nozzles can be arranged with respect to fenders of the rear wheels, so that the rear wheel nozzles move laterally with the rear wheels.