- Patent Title: Small molecule inhibitors of USP1 deubiquitinating enzyme activity
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Application No.: US15342175Application Date: 2016-11-03
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Publication No.: US10653676B2Publication Date: 2020-05-19
- Inventor: Alan D. D'Andrea , Gregory D. Cuny , Ross L. Stein , Marcie Glicksman , April Case , Jun Xian , David Wilson , Min Huang
- Applicant: Dana-Farber Cancer Institute, Inc. , The Brigham and Women's Hospital, Inc.
- Applicant Address: US MA Boston US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.,The Brigham and Women's Hospital, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.,The Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K31/423
- IPC: A61K31/423 ; C07D405/06 ; C07D263/60 ; A61K31/136 ; A61K31/472 ; A61K31/4725 ; A61K45/06 ; C07C225/30 ; C07D217/24
Abstract:
Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.
Public/Granted literature
- US20170202810A1 SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY Public/Granted day:2017-07-20
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