Invention Grant
- Patent Title: 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
-
Application No.: US15755475Application Date: 2016-08-25
-
Publication No.: US10653711B2Publication Date: 2020-05-19
- Inventor: Tongfei Wu , Dirk Brehmer , Lijs Beke , An Boeckx , Gaston Stanislas Marcella Diels , Ronaldus Arnodus Hendrika Joseph Gilissen , Edward Charles Lawson , Vineet Pande , Marcus Cornelis Bernardus Catharina Paradé , Wim Bert Griet Schepens , Johannes Wilhelmus John F. Thuring , Marcel Viellevoye , Weimei Sun , Lieven Meerpoel
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5d96d566
- International Application: PCT/EP2016/070097 WO 20160825
- International Announcement: WO2017/032840 WO 20170302
- Main IPC: A61K31/7076
- IPC: A61K31/7076 ; A61K31/519 ; A61K31/53 ; C07D471/04 ; A61P35/00 ; A61K31/5025
Abstract:
Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound: Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).
Public/Granted literature
- US20180243328A1 NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS Public/Granted day:2018-08-30
Information query
IPC分类:
