Invention Grant
- Patent Title: Crystal form of tasimelteon
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Application No.: US16300303Application Date: 2017-02-19
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Publication No.: US10654820B2Publication Date: 2020-05-19
- Inventor: Jianrong Zhu , Chunyong Peng , Hongban Zhong , Xiurong Hu
- Applicant: ZHEJIANG JINGXIN PHARMACEUTICAL CO., LTD.
- Applicant Address: CN Shaoxing, Zhejiang
- Assignee: ZHEJIANG JINGXIN PHARMACEUTICAL CO., LTD.
- Current Assignee: ZHEJIANG JINGXIN PHARMACEUTICAL CO., LTD.
- Current Assignee Address: CN Shaoxing, Zhejiang
- Agency: Proi Intellectual Property US
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5c565a28
- International Application: PCT/CN2017/074030 WO 20170219
- International Announcement: WO2017/193662 WO 20171116
- Main IPC: C07D307/79
- IPC: C07D307/79 ; A61K31/343 ; B01D9/00 ; A61P25/20

Abstract:
Crystal forms I and II of tasimelteon. Crystal form I: an X-ray powder diffraction spectrum using CuKα radiation and represented by a 2θ angle has diffraction peaks at least at 7.2°±0.2°, 7.9°±0.2°, 10.6°±0.2°, 14.4°±0.2°, 15.9°±0.2°, 17.3°±0.2°, 21.0°±0.2°, 23.2°±0.2°, and 24.4°±0.2°. Crystal form II: an X-ray powder diffraction spectrum using CuKα radiation and represented by a 2θ angle has diffraction peaks at least at 6.8°±0.2°, 12.1°±0.2°, 12.5°±0.2°, 13.1°±0.2°, 13.6°±0.2°, 13.8°±0.2°, 15.8°±0.2°, 17.0°±0.2°, 18.4°±0.2°, 20.8°±0.2°, 24.2°±0.2°, and 24.4°±0.2°. Crystal forms I and II of tasimelteon have advantages of excellent physicochemical property, good stability and solubility, and simple operation for preparation.
Public/Granted literature
- US20190119239A1 CRYSTAL FORM OF TASIMELTEON Public/Granted day:2019-04-25
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