Invention Grant
- Patent Title: Aligning a non-spherical biological entity in a sample flow using ambient viscoelastic fluid flows
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Application No.: US16090205Application Date: 2016-03-30
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Publication No.: US10656070B2Publication Date: 2020-05-19
- Inventor: Oliver Hayden , Lukas Richter , Matthias Ugele
- Applicant: Siemens Healthcare GmbH
- Applicant Address: DE Erlangen
- Assignee: Siemens Healthcare GmbH
- Current Assignee: Siemens Healthcare GmbH
- Current Assignee Address: DE Erlangen
- Agency: Dugan & Dugan, PC
- International Application: PCT/EP2016/056955 WO 20160330
- International Announcement: WO2017/167361 WO 20171005
- Main IPC: G01N15/14
- IPC: G01N15/14 ; B01L3/00 ; G01N21/45 ; G01N15/10 ; G01N15/00

Abstract:
A technique is presented for aligning, in a desired region within a flow chamber of a flow cell, a non-spherical biological entity carried in a sample. The flow chamber has a rectangular cross-section. A bottom flow input module, a top flow input module and a sample input module provide a viscoelastic first fluid, a second viscoelastic fluid, and the sample, respectively, to the flow chamber. The first and the second viscoelastic fluids laminarly flow along a bottom and a top wall of the flow chamber and the sample laminarly flows sandwiched between them. By controlling rate of flow of the first and/or the second viscoelastic fluids the sample flow, and thus the non-spherical biological entity, is focused in the desired region. A gradient of sheer within the sample flow set up due to the first and second viscoelastic fluids orients the non-spherical biological entity in the desired region.
Public/Granted literature
- US20190113433A1 ALIGNING A NON-SPHERICAL BIOLOGICAL ENTITY IN A SAMPLE FLOW USING AMBIENT VISCOELASTIC FLUID FLOWS Public/Granted day:2019-04-18
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