The present embodiments relate to buffering signals between disjointed power domains with similar power profiles in an integrated circuit. According to some aspects, embodiments relate to a method in which an electronic design automation (EDA) tool displays a schematic including a plurality of first power domains having a first power profile and a plurality of second power domains having a second power profile. The EDA tool generates graph including a plurality of points and a plurality of edges connecting the points, where the points are located on the plurality of second power domains. The EDA tool selects one route from a plurality of routes from a start node on the graph to an end node on the graph and determines a number of buffers located on the route based on associated distance values and a design violation values.