Method for generating a test-set for inspection of a design being printed by a printing-press, each color-unit in the printing-press prints a respective color. The design is composed of original-layers. Inspection includes determining the origin of at least one defect in the printed-design. The method includes the procedures of generating defective-layer or layers of the design, by introducing at least one selected defect to at least one selected original-layer, in a selected location or locations and combining layers using a trained-synthesis-neural-network. The layers include the defective-layer or layers and remaining ones of the original-layers. The trained-synthesis-neural-network provides a plurality of features respective of each pixel. The method also includes the procedure of generating the test-set from the output of the synthesis-neural-network. The test-set includes at least one synthesized-test-image. The synthesized-test-image includes at least one synthesized-defect at the selected location. The test-set is employed to determine the origin of the defect.