A pixel driving circuit, a driving method thereof and an OLED display panel are provided. A plurality of scanning lines and a plurality of data lines of the pixel driving circuit intersect to define a plurality of pixel units, the plurality of pixel units in each row are connected to a corresponding scanning line and a corresponding power line, the plurality of pixel units in each column are connected to a corresponding data line, in a scanning period, scanning signal is input to an end of the scanning line to drive the plurality of pixel units along a first direction, power driving signal is input to an end of the power line opposite to the end of the scanning line to which the scanning signal is input to drive the plurality of pixel units along a second direction, the first direction and the second direction are opposite.