An array substrate and a manufacturing method thereof, a display panel and a display device are provided. The array substrate includes: a base substrate; a first electrode layer including a plurality of pixel electrode pairs arranged in an array, each of the plurality of pixel electrode pairs (1110; 2100) including a first pixel electrode and a second pixel electrode adjacent to the first pixel electrode in a row direction; and a first common portion, an orthographic projection of the first common portion on the base substrate being at least partially overlapped with an orthographic projection of at least one of adjacent first pixel electrode or second pixel electrode of two adjacent pixel electrode pairs in the row direction on the base substrate.