Systems and methods for routing real-time voice communication via a private network exchange. A virtual private cloud (VPC) system receives first configuration for a first private network exchange for a first account of the VPC system. The VPC system assigns a first regional exchange system to the first private network exchange based on the first configuration. The first private network exchange is established between the first regional exchange system and a first outside entity system of the first account by mapping an identifier of the first account to the first private network exchange. Real-time voice communication data for the first account is routed from a first real-time voice communication service of the VPC system to the first outside entity system via the first private network exchange based on the mapping.