The disclosure herein describes automatically unsubscribing from automated calls based on automated call audio patterns. Audio data of an incoming call is accessed and an incoming call audio pattern is generated based on the audio data of the incoming call. The incoming call audio pattern is compared to an automated call audio pattern set by a call screening engine. Based on the comparison, the user is prompted for a call response instruction. Based on the call response instruction from the user, the call screening engine identifies an unsubscribe operation indication in the incoming call audio pattern, performs an unsubscribe operation associated with the identified unsubscribe operation indication, and updates the automated call audio pattern set based on the incoming call audio pattern. The disclosure enables efficient handling of automated calls and reduces user interaction necessary to unsubscribe from associated call lists.