In a to-be-cooled body protection structure of a saddle-ridden vehicle, a guard member protects at least a front portion of a to-be-cooled body requiring cooling with a travelling air, straddles over a pair of left and right frame members, is supported to the body frame, and located at a rear of a front wheel. A plurality of through-holes are provided on the guard member, each include at least one linear edge portion linearly extending, and are formed into non-circular shapes. The non-circular through-holes are arranged such that linear ribs are formed between linear edge portions, as said linear edge portion, facing each other of adjacent ones of the non-circular through-holes. Accordingly, while protecting the to-be-cooled body from a small stone etc. jumped up by the front wheel, a larger amount of travelling air is guided to the to-be-cooled body side.