A manufacturing method of a honeycomb structure includes a forming step of forming a honeycomb formed body by use of a kneaded material containing a cordierite forming raw material, a slurry coating step of coating a coating layer forming slurry which contains a cordierite forming raw material on four regions in a rotation area when each of two straight lines passing through the center of gravity of the cross section and extending in a diagonal direction of main quadrangular cells is rotated in a range of ±x° of the center of gravity in a circumferential surface, and a firing step of firing the honeycomb formed body on which the slurry is coated. The value x is in a range of 7 to 45, and the slurry is adjusted so that the coating layer has a porosity higher than that of the honeycomb structure body as much as 5% or more.