Invention Grant
- Patent Title: ABHD6 and dual ABHD6/MGL inhibitors and their uses
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Application No.: US16198261Application Date: 2018-11-21
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Publication No.: US10662159B2Publication Date: 2020-05-26
- Inventor: Alexandros Makriyannis , Michael Malamas , Manjunath Lamani , Shrouq I. Farah
- Applicant: MAKScientific, LLC
- Applicant Address: US MA Burlington
- Assignee: MAKSCIENTIFIC, LLC
- Current Assignee: MAKSCIENTIFIC, LLC
- Current Assignee Address: US MA Burlington
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: C07D217/04
- IPC: C07D217/04 ; C07D209/44 ; C07D471/04 ; C07D223/16 ; C07D401/12 ; C07D205/12 ; C07D217/06 ; C07D413/12 ; C07D401/14 ; C07D403/12
Abstract:
Provided herein are compounds and pharmaceutical compositions for selectively inhibiting serine hydrolase a/b-hydrolase domain 6 (ABHD6) and dually inhibiting ABHD6 and monoacylglycerol lipase (MGL). The compounds and pharmaceutical compositions disclosed herein are useful for treating a number of therapeutic conditions related to cannabinergic receptor function such as pain, inflammation, neuropathy, neurodegenerative diseases, anxiety disorders, motor function disorder, metabolic disorder, glaucoma and chemotherapy-induced nausea and vomiting and cancer.
Public/Granted literature
- US20190152917A1 ABHD6 AND DUAL ABHD6/MGL INHIBITORS AND THEIR USES Public/Granted day:2019-05-23
Information query
