Invention Grant
- Patent Title: Protein kinase conjugates and inhibitors
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Application No.: US15213319Application Date: 2016-07-18
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Publication No.: US10662195B2Publication Date: 2020-05-26
- Inventor: Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
- Applicant: Celgene Avilomics Research, Inc.
- Applicant Address: BM Pembroke
- Assignee: Celgene CAR LLC
- Current Assignee: Celgene CAR LLC
- Current Assignee Address: BM Pembroke
- Agency: Jones Day
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D401/12 ; C07D401/14 ; C07D213/74 ; C07D213/81 ; C07D213/82 ; C07D215/22 ; C07D231/12 ; C07D239/42 ; C07D239/48 ; C07D333/68 ; C07D403/04 ; C07D403/06 ; C07D403/12 ; C07D403/14 ; C07D409/04 ; C07D409/12 ; C07D409/14 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14 ; C07D471/04 ; C07D471/10 ; C07D495/04 ; C07D498/04 ; C12N9/12 ; A61K47/54 ; A61K47/62 ; C12N9/96 ; C07D213/72
Abstract:
The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.
Public/Granted literature
- US20170174691A1 Protein Kinase Conjugates and Inhibitors Public/Granted day:2017-06-22
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