Invention Grant
- Patent Title: Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome
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Application No.: US16342169Application Date: 2017-10-13
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Publication No.: US10662416B2Publication Date: 2020-05-26
- Inventor: Derek Jantz , James Jefferson Smith
- Applicant: Precision BioSciences, Inc.
- Applicant Address: US NC Durham
- Assignee: Precision BioSciences, Inc.
- Current Assignee: Precision BioSciences, Inc.
- Current Assignee Address: US NC Durham
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2017/056638 WO 20171013
- International Announcement: WO2018/071849 WO 20180419
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N9/22 ; C12N15/00 ; A61K38/46 ; C07K14/435 ; A61P31/20 ; A61K9/51 ; A61K38/43 ; C12N15/52 ; C12N15/86 ; A61K38/00
Abstract:
The present invention encompasses engineered meganucleases which recognize and cleave a recognition sequence within an open reading frame (ORF) of the genome of at least two genotypes of the Hepatitis B virus (HBV). The present invention also encompasses methods of using such engineered meganucleases in a pharmaceutical composition and in methods for treating or reducing the symptoms of a HBV infection, or treating hepatocellular carcinoma (HCC). Further, the invention encompasses pharmaceutical compositions comprising engineered meganuclease proteins, nucleic acids encoding engineered meganucleases, and the use of such compositions for treating HBV infections or HCC.
Public/Granted literature
- US20190284543A1 ENGINEERED MEGANUCLEASES SPECIFIC FOR RECOGNITION SEQUENCES IN THE HEPATITIS B VIRUS GENOME Public/Granted day:2019-09-19
Information query
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