Invention Grant
- Patent Title: Fluorescent sensors of peroxynitrite targeted to the endoplasmic reticulum
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Application No.: US16362280Application Date: 2019-03-22
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Publication No.: US10663471B2Publication Date: 2020-05-26
- Inventor: Blake R. Peterson , Digamber Rane
- Applicant: The University of Kansas
- Applicant Address: US KS Lawrence
- Assignee: The University of Kansas
- Current Assignee: The University of Kansas
- Current Assignee Address: US KS Lawrence
- Agency: Maschoff Brennan
- Agent Jonathan M. Benns
- Main IPC: G01N33/58
- IPC: G01N33/58 ; G01N33/533 ; G01N33/50 ; C09B57/00
Abstract:
A compound can be a pro-fluorophore peroxynitrite sensor that generates a fluorophore when cleaved by peroxynitrite, having a structure of Formula A: wherein: moiety A is an ER-targeting fluorophore; Y is a linker; and moiety B is a phenol, substituted or unsubstituted, wherein the structure of Formula A is less fluorescent than the ER-targeting fluorophore moiety A.
Public/Granted literature
- US20190310263A1 FLUORESCENT SENSORS OF PEROXYNITRITE TARGETED TO THE ENDOPLASMIC RETICULUM Public/Granted day:2019-10-10
Information query
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