Embodiments described herein relate to systems, devices, and methods for use in the implementation of a human-computer interface using high-speed, and efficient tracking of user interactions with a User Interface/User Experience that is strategically presented to the user. Embodiments described herein also relate to the implementation of a hardware agnostic human-computer interface that uses neural, oculomotor, and/or electromyography signals to mediate user manipulation of machines and devices.