Methods, apparatus, and processor-readable storage media for dynamically generating system-compatible transaction requests derived from external information are provided herein. An example computer-implemented method includes converting portions of a transaction request to items of text, wherein the transaction request is derived from a source external to a transaction request processing system; extracting items of information associated with the transaction request processing system from the items of text via one or more machine learning algorithms; dynamically generating a modified version of the transaction request based at least in part on the extracted items of information and one or more items of historical information related to the extracted items of information, wherein the modified version of the transaction request is compatible with the transaction request processing system; and outputting the modified version of the transaction request to the transaction request processing system.