Embodiments are disclosed for predicting a response (e.g., an answer responding to a question) using an end-to-end memory network model. A computing device according to some embodiments includes embedding matrices to convert knowledge entries and an inquiry into feature vectors including the input vector and memory vectors. The device further execute a hop operation to generate a probability vector based on an input vector and a first set of memory vectors using a continuous weighting function (e.g., softmax), and to generate an output vector as weighted combination of a second set of memory vectors using the elements of the probability vector as weights. The device can repeat the hop operation for multiple times, where the input vector for a hop operation depends on input and output vectors of previous hop operation(s). The device generates a predicted response based on at least the output of the last hop operation.