A building monitoring and control system in furtherance of engaging a detected and targeted threat to persons in or about the building is provided. The system is characterized by a threat detection module, a threat targeting module, a threat tracking module, and threat engaging assemblies. The threat detection module is provided in the form of a multi-modal sensor array or network system deployable or integral with a monitored building. Threat targeting and tracking modules are operatively linked to the threat detection module, and each other. Threat engaging assemblies, in the form of water cannons selectively deployable or integral with a monitored building, are operatively linked to at least the tracking module in furtherance of disrupting a located and trackable threat with water discharged from multiple water discharge nozzles of the water cannons.