An apparatus of a wireless device can include baseband processing circuitry configured to generate a digitized downconverted signal based on a received radio frequency (RF) signal. The apparatus can also include estimation circuitry configured to detect a blocker signal in the downconverted signal, the blocker signal having power that exceeds a pre-determined threshold, and map the detected blocker signal to a plurality of harmonic frequencies associated with two or more carrier frequencies. The apparatus can include reference signal generation circuitry configured to generate a reference signal based on the plurality of harmonic frequencies and the received RF signal. The apparatus can include cancellation circuitry configured to apply a pre-processed reference signal (based on the reference signal) to the digitized downconverted signal to remove distortion associated with the detected blocker signal. The digitized downconverted signal is a baseband signal or an intermediate frequency (IF) signal.