A tissue specimen retrieval device includes a housing having an outer shaft that extends distally therefrom and that defines a longitudinal axis. An end effector assembly is included that extends distally from the outer shaft in a deployed position of the end effector assembly. A first actuator is operably associated with the housing and actuatable to deploy and retract the end effector assembly. A second actuator is operably associated with the housing and actuatable to move a four-bar articulation mechanism including first, second and third movable links and a stationary link coupled together by respective first, second and third pivots. Actuation of the second actuator moves the first link distally which forces the second and third links to rotate in opposing directions about the first and second pivots which, in turn, forces at least one of the first or second links against the end effector assembly to articulate the same.