An anvil for a surgical end effector is disclosed. The anvil can have a staple-forming surface having a plurality of pockets defined therein. The pockets can be nested. A first pocket can include a proximal cup, a distal cup, and a pocket axis can extend between the proximal cup and the distal cup. The pocket can be asymmetric relative to the pocket axis. A central axis can transect the pocket between the proximal cup and the distal cup. The pocket can also be asymmetric relative to the central axis. The pockets can be obliquely oriented relative to a longitudinal axis of the anvil.