Invention Grant
- Patent Title: Micelle composition for nucleic acid delivery using temperature-sensitive polymer and method for producing same
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Application No.: US15575716Application Date: 2016-05-20
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Publication No.: US10668169B2Publication Date: 2020-06-02
- Inventor: Kazunori Kataoka , Yasutaka Anraku , Kanjiro Miyata , Meng Zheng , Shigehito Osawa
- Applicant: The University of Tokyo
- Applicant Address: JP Tokyo
- Assignee: The University of Tokyo
- Current Assignee: The University of Tokyo
- Current Assignee Address: JP Tokyo
- Agency: Clark & Elbing LLP
- Agent Susan M. Michaud
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5d10d7fb
- International Application: PCT/JP2016/065052 WO 20160520
- International Announcement: WO2016/186204 WO 20161124
- Main IPC: A61K47/69
- IPC: A61K47/69 ; A61K31/713 ; A61K47/34 ; A61K31/7105 ; A61K47/50 ; A61K47/42 ; A61K47/32 ; A61K9/00 ; A61K47/64 ; A61K47/54 ; A61K47/60 ; A61K47/59 ; A61K9/107 ; C12N15/113

Abstract:
Provided are a micelle composition for nucleic acid delivery using a temperature-sensitive polymer, and a method for producing the micelle. For example, provided is a polyion complex comprising a temperature-sensitive copolymer and a nucleic acid, wherein the temperature-sensitive copolymer comprises a cationic block and a temperature-sensitive block, the cationic block optionally carrying a hydrophilic block linked thereto, and the polyion complex is obtained by mixing the temperature-sensitive copolymer with the nucleic acid under temperature conditions equal to or lower than the lower critical solution temperature (LCST) of the temperature-sensitive copolymer.
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